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Dog  Prescription Medicines  

Advantix Spot-on solution for dogs

£26.18

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Advantix Spot-on solution for dogs Species: Dogs Therapeutic indication: Pharmaceuticals: Ectoparasiticides: For dogs Active ingredient: Imidacloprid, Permethrin Product:Advantix Spot-on solution for dogs Product index: Advantix Spot-on solution for dogs Incorporating:Advantix Spot-on solution for dogs up to 4 kg Advantix Spot-on solution for dogs over 4 kg up to 10 kg Advantix Spot-on solution for dogs over 10 kg up to 25 kg Advantix Spot-on solution for dogs over 25 kg up to 40 kg Clinical particulars Target species Dogs Use the appropriate Advantix Spot-on solution product (see section Amounts to be administered and administration route). Indications for use, specifying the target species For the treatment and prevention of flea (Ctenocephalides canis, Ctenocephalides felis) infestation. Fleas on dogs are killed within one day following treatment. One treatment prevents further flea infestation for four weeks. The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD). For the treatment of biting lice (Trichodectes canis). The product has persistent acaricidal and repellent efficacy against tick infestations (Rhipicephalus sanguineus and Ixodes ricinus for four weeks, and Dermacentor reticulatus for three weeks). By repelling and killing the tick vector Rhipicephalus sanguineus, the product reduces the likelihood of transmission of the pathogen Ehrlichia canis, thereby reducing the risk of canine ehrlichiosis. The reduction in risk has been shown in studies to commence from 3 days following application of the product and to persist for 4 weeks. Ticks already on the dog may not be killed within two days after treatment and may remain attached and visible. Therefore the removal of ticks already on the dog at the time of treatment is recommended, in order to prevent them from attaching and having a blood meal. One treatment provides repellent (anti-feeding) activity against sand flies (Phlebotomus papatasi for two weeks and Phlebotomus perniciosus for three weeks), against mosquitoes (Aedes aegypti for two weeks and Culex pipiens for four weeks) and against stable flies (Stomoxys calcitrans) for four weeks. Reduction of the risk of infection with Leishmania infantum via transmission by sandflies (Phlebotomus perniciosus) for up to 3 weeks. The effect is indirect due to product’s activity against the vector. Contraindications In the absence of available data the product should not be used on puppies of less than 7 weeks of age or 1.5 kg of weight. According to the dog’s body weight the corresponding Advantix product must be used, see dosing scheme. Do not use in cases of hypersensitivity to the active substances or to any of the excipients. Do not use on cats. (Refer to section – Special precautions for use). Special warnings for each target species There may be an attachment of single ticks or bites by single sand flies or mosquitoes. For this reason, a transmission of infectious diseases by these parasites cannot be completely excluded if conditions are unfavourable. It is recommended to apply the treatment at least 3 days before expected exposure to E. canis. With regard to E. canis, studies have demonstrated a reduced risk of canine ehrlichiosis in dogs exposed to Rhipicephalus sanguineusticks infected with E. canis from 3 days following application of the product and to persist for 4 weeks. Immediate protection against sandflies bites is not documented. Treated dogs for the reduction of the risk of infection with Leishmania infantum via transmission by sandflies P. perniciosus should be kept in a protected environment during the first 24 hours after the initial treatment application. Special precautions for use Special precautions for use in animals Care should be taken to avoid the content of the pipette coming into contact with the eyes or mouth of the recipient dogs. Care should be taken to administer the product correctly as described under section Amounts to be administered and administration route. In particular oral uptake due to the licking of the application site by treated or in-contact animals should be avoided. Do not use on cats. This product is extremely poisonous to cats and could be fatal due to the unique physiology of cats which is unable to metabolise certain compounds including permethrin. To prevent cats from being accidentally exposed to the product, keep treated dogs away from cats after treatment until the application site is dry. It is important to ensure that cats do not groom the site of application on a dog, which has been treated with this product. Seek veterinary advice immediately if this occurs. Consult your veterinary surgeon before using the product on sick and debilitated dogs. Special precautions to be taken by the person administering the veterinary medicinal product to animals Avoid contact between the product and skin, eyes or mouth. Do not eat, drink or smoke during application. Wash hands thoroughly after use. In case of accidental spillage onto skin, wash off immediately with soap and water. People with known skin sensitivity may be particularly sensitive to this product. The predominant clinical symptoms that in extremely rare case may be shown are transient sensory irritations of the skin like tingling, burning sensation or numbness. If the product gets accidentally into the eyes, they should be thoroughly flushed with water. If skin or if eye irritation persists obtain medical attention immediately and show the package insert to the physician. Do not ingest. In case of accidental ingestion seek medical advice immediately and show the package leaflet or the label to the physician. Treated dogs should not be handled especially by children until the application site is dry. This may be ensured by treating the dogs e.g. in the evening. Recently treated dogs should not be allowed to sleep together with their owner, especially children. In order to prevent children from getting access to pipettes, keep the pipette in the original packaging until ready for use and dispose of used pipettes immediately. Other precautions As the product is dangerous to aquatic organisms, treated dogs must not under any circumstances be allowed into any type of surface water for at least 48 hours after treatment. The solvent in Advantix Spot-on solution may stain certain materials including leather, fabrics, plastics and finished surfaces. Allow the application site to dry before permitting contact with such materials. Adverse reactions (frequency and seriousness) Application site itching and hair change (e.g. greasy fur) and vomiting were uncommonly observed in clinical studies. Other reactions like redness, inflammation and hair loss at the application site and diarrhoea were reported rarely. On very rare occasions reactions in dogs including transient skin sensitivity (scratching and rubbing) or lethargy were reported in spontaneous (pharmacovigilance) reports. These reactions are generally self-resolving. In very rare cases dogs may show behaviour changes (agitation, restlessness, whining or rolling), gastro-intestinal symptoms (hypersalivation, diminished appetite) and neurological signs such as unsteady movement and twitching in dogs susceptible to the ingredient permethrin. These signs are generally transient and self-resolving. Poisoning following inadvertent oral uptake in dogs is unlikely but may occur in very rare cases. In this event, neurological signs such as tremor and lethargy can occur. Treatment should be symptomatic. There is no known specific antidote. The frequency of adverse reactions is defined using the following convention: - very common (more than 1 in 10 animals treated displaying adverse reaction(s)) - common (more than 1 but less than 10 animals in 100 animals treated) - uncommon (more than 1 but less than 10 animals in 1,000 animals treated) - rare (more than 1 but less than 10 animals in 10,000 animals treated) - very rare (less than 1 animal in 10,000 animals treated, including isolated reports). Use during pregnancy, lactation or lay Can be used during pregnancy and lactation. Interaction with other medicinal products and other forms of interaction None known. Amounts to be administered and administration route The recommended minimum dose is: 10 mg/kg body weight (bw) imidacloprid and 50 mg/kg body weight (bw) permethrin. Dosing Scheme for Advantix Spot-on: Dogs (kg body weight) Trade name Volume (ml) Imidacloprid (mg/kg body weight) Permethrin (mg/kg body weight) ≤ 4 kg Advantix Spot-on for dogs up to 4 kg 0.4 ml minimum of 10 minimum of 50 >4 kg ≤ 10 kg Advantix Spot-on for dogs over 4 kg up to 10 kg 1.0 ml 10 - 25 50 - 125 >10 kg ≤ 25 kg Advantix Spot-on for dogs over 10 kg up to 25 kg 2.5 ml 10 - 25 50 - 125 >25 kg ≤ 40 kg Advantix Spot-on for dogs over 25 kg up to 40 kg 4.0 ml 10 - 16 50 - 80 >40 kg The appropriate combination of pipettes should be used To reduce re-infestation from emergence of new fleas, it is recommended to treat all dogs in a household. Other animals living in the same household should also be treated with a suitable product. To aid further in reducing environmental challenge, the additional use of a suitable environmental treatment against adult fleas and their developmental stages is recommended. The product remains effective if the animal becomes wet. However, prolonged, intense exposure to water should be avoided. In cases of frequent water exposure the persistent efficacy may be reduced. In these cases do not retreat more frequently than once weekly. If a dog requires a shampoo, it should be administered before applying Advantix or at least 2 weeks after application, to optimise efficacy of the product. In case of biting louse infestation, a further veterinary examination 30 days after treatment is recommended as some animals may require a second treatment. To protect a dog over the whole sand fly season, treatment should be compliantly continued throughout. For dermal use only. Apply only to undamaged skin. Method for administration for short-neck tubes Method for administration Remove one pipette from the package. Hold applicator pipette in an upright position, twist and pull cap off. Turn the cap around and place the other end of cap back on pipette. Twist cap to break seal, then remove cap from pipette. For dogs 10 kg body weight or less: For dogs of more than 10 kg body weight: With the dog standing still, part the coat between the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze firmly several times to empty the contents directly onto the skin. With the dog standing still, the entire contents of the Advantix pipette should be applied evenly to four spots on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the pipette on the skin and gently squeeze to expel a portion of the solution on the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog. Remove one pipette from the package. Hold applicator pipette in an upright position, twist and pull cap off. Turn the cap around and place the other end of cap back on pipette. Twist cap to break seal, then remove cap from pipette. Overdose (symptoms, emergency procedures, antidotes), if necessary No adverse clinical signs were noted in healthy puppies or adult dogs exposed to 5x overdosage or for puppies whose mothers were treated with 3x overdosage of the product. Withdrawal period(s) Not applicable.

  • Availability: In stock

  • Tags: Flea treatment, Dog

  • Product Code: #145312

  • Weight: 37gm

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Advantix Spot-on solution for dogs Species: Dogs Therapeutic indication: Pharmaceuticals: Ectoparasiticides: For dogs Active ingredient: Imidacloprid, Permethrin Product:Advantix Spot-on solution for dogs Product index: Advantix Spot-on solution for dogs Incorporating:Advantix Spot-on solution for dogs up to 4 kg Advantix Spot-on solution for dogs over 4 kg up to 10 kg Advantix Spot-on solution for dogs over 10 kg up to 25 kg Advantix Spot-on solution for dogs over 25 kg up to 40 kg Clinical particulars Target species Dogs Use the appropriate Advantix Spot-on solution product (see section Amounts to be administered and administration route). Indications for use, specifying the target species For the treatment and prevention of flea (Ctenocephalides canis, Ctenocephalides felis) infestation. Fleas on dogs are killed within one day following treatment. One treatment prevents further flea infestation for four weeks. The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD). For the treatment of biting lice (Trichodectes canis). The product has persistent acaricidal and repellent efficacy against tick infestations (Rhipicephalus sanguineus and Ixodes ricinus for four weeks, and Dermacentor reticulatus for three weeks). By repelling and killing the tick vector Rhipicephalus sanguineus, the product reduces the likelihood of transmission of the pathogen Ehrlichia canis, thereby reducing the risk of canine ehrlichiosis. The reduction in risk has been shown in studies to commence from 3 days following application of the product and to persist for 4 weeks. Ticks already on the dog may not be killed within two days after treatment and may remain attached and visible. Therefore the removal of ticks already on the dog at the time of treatment is recommended, in order to prevent them from attaching and having a blood meal. One treatment provides repellent (anti-feeding) activity against sand flies (Phlebotomus papatasi for two weeks and Phlebotomus perniciosus for three weeks), against mosquitoes (Aedes aegypti for two weeks and Culex pipiens for four weeks) and against stable flies (Stomoxys calcitrans) for four weeks. Reduction of the risk of infection with Leishmania infantum via transmission by sandflies (Phlebotomus perniciosus) for up to 3 weeks. The effect is indirect due to product’s activity against the vector. Contraindications In the absence of available data the product should not be used on puppies of less than 7 weeks of age or 1.5 kg of weight. According to the dog’s body weight the corresponding Advantix product must be used, see dosing scheme. Do not use in cases of hypersensitivity to the active substances or to any of the excipients. Do not use on cats. (Refer to section – Special precautions for use). Special warnings for each target species There may be an attachment of single ticks or bites by single sand flies or mosquitoes. For this reason, a transmission of infectious diseases by these parasites cannot be completely excluded if conditions are unfavourable. It is recommended to apply the treatment at least 3 days before expected exposure to E. canis. With regard to E. canis, studies have demonstrated a reduced risk of canine ehrlichiosis in dogs exposed to Rhipicephalus sanguineusticks infected with E. canis from 3 days following application of the product and to persist for 4 weeks. Immediate protection against sandflies bites is not documented. Treated dogs for the reduction of the risk of infection with Leishmania infantum via transmission by sandflies P. perniciosus should be kept in a protected environment during the first 24 hours after the initial treatment application. Special precautions for use Special precautions for use in animals Care should be taken to avoid the content of the pipette coming into contact with the eyes or mouth of the recipient dogs. Care should be taken to administer the product correctly as described under section Amounts to be administered and administration route. In particular oral uptake due to the licking of the application site by treated or in-contact animals should be avoided. Do not use on cats. This product is extremely poisonous to cats and could be fatal due to the unique physiology of cats which is unable to metabolise certain compounds including permethrin. To prevent cats from being accidentally exposed to the product, keep treated dogs away from cats after treatment until the application site is dry. It is important to ensure that cats do not groom the site of application on a dog, which has been treated with this product. Seek veterinary advice immediately if this occurs. Consult your veterinary surgeon before using the product on sick and debilitated dogs. Special precautions to be taken by the person administering the veterinary medicinal product to animals Avoid contact between the product and skin, eyes or mouth. Do not eat, drink or smoke during application. Wash hands thoroughly after use. In case of accidental spillage onto skin, wash off immediately with soap and water. People with known skin sensitivity may be particularly sensitive to this product. The predominant clinical symptoms that in extremely rare case may be shown are transient sensory irritations of the skin like tingling, burning sensation or numbness. If the product gets accidentally into the eyes, they should be thoroughly flushed with water. If skin or if eye irritation persists obtain medical attention immediately and show the package insert to the physician. Do not ingest. In case of accidental ingestion seek medical advice immediately and show the package leaflet or the label to the physician. Treated dogs should not be handled especially by children until the application site is dry. This may be ensured by treating the dogs e.g. in the evening. Recently treated dogs should not be allowed to sleep together with their owner, especially children. In order to prevent children from getting access to pipettes, keep the pipette in the original packaging until ready for use and dispose of used pipettes immediately. Other precautions As the product is dangerous to aquatic organisms, treated dogs must not under any circumstances be allowed into any type of surface water for at least 48 hours after treatment. The solvent in Advantix Spot-on solution may stain certain materials including leather, fabrics, plastics and finished surfaces. Allow the application site to dry before permitting contact with such materials. Adverse reactions (frequency and seriousness) Application site itching and hair change (e.g. greasy fur) and vomiting were uncommonly observed in clinical studies. Other reactions like redness, inflammation and hair loss at the application site and diarrhoea were reported rarely. On very rare occasions reactions in dogs including transient skin sensitivity (scratching and rubbing) or lethargy were reported in spontaneous (pharmacovigilance) reports. These reactions are generally self-resolving. In very rare cases dogs may show behaviour changes (agitation, restlessness, whining or rolling), gastro-intestinal symptoms (hypersalivation, diminished appetite) and neurological signs such as unsteady movement and twitching in dogs susceptible to the ingredient permethrin. These signs are generally transient and self-resolving. Poisoning following inadvertent oral uptake in dogs is unlikely but may occur in very rare cases. In this event, neurological signs such as tremor and lethargy can occur. Treatment should be symptomatic. There is no known specific antidote. The frequency of adverse reactions is defined using the following convention: - very common (more than 1 in 10 animals treated displaying adverse reaction(s)) - common (more than 1 but less than 10 animals in 100 animals treated) - uncommon (more than 1 but less than 10 animals in 1,000 animals treated) - rare (more than 1 but less than 10 animals in 10,000 animals treated) - very rare (less than 1 animal in 10,000 animals treated, including isolated reports). Use during pregnancy, lactation or lay Can be used during pregnancy and lactation. Interaction with other medicinal products and other forms of interaction None known. Amounts to be administered and administration route The recommended minimum dose is: 10 mg/kg body weight (bw) imidacloprid and 50 mg/kg body weight (bw) permethrin. Dosing Scheme for Advantix Spot-on: Dogs (kg body weight) Trade name Volume (ml) Imidacloprid (mg/kg body weight) Permethrin (mg/kg body weight) ≤ 4 kg Advantix Spot-on for dogs up to 4 kg 0.4 ml minimum of 10 minimum of 50 >4 kg ≤ 10 kg Advantix Spot-on for dogs over 4 kg up to 10 kg 1.0 ml 10 - 25 50 - 125 >10 kg ≤ 25 kg Advantix Spot-on for dogs over 10 kg up to 25 kg 2.5 ml 10 - 25 50 - 125 >25 kg ≤ 40 kg Advantix Spot-on for dogs over 25 kg up to 40 kg 4.0 ml 10 - 16 50 - 80 >40 kg The appropriate combination of pipettes should be used To reduce re-infestation from emergence of new fleas, it is recommended to treat all dogs in a household. Other animals living in the same household should also be treated with a suitable product. To aid further in reducing environmental challenge, the additional use of a suitable environmental treatment against adult fleas and their developmental stages is recommended. The product remains effective if the animal becomes wet. However, prolonged, intense exposure to water should be avoided. In cases of frequent water exposure the persistent efficacy may be reduced. In these cases do not retreat more frequently than once weekly. If a dog requires a shampoo, it should be administered before applying Advantix or at least 2 weeks after application, to optimise efficacy of the product. In case of biting louse infestation, a further veterinary examination 30 days after treatment is recommended as some animals may require a second treatment. To protect a dog over the whole sand fly season, treatment should be compliantly continued throughout. For dermal use only. Apply only to undamaged skin. Method for administration for short-neck tubes Method for administration Remove one pipette from the package. Hold applicator pipette in an upright position, twist and pull cap off. Turn the cap around and place the other end of cap back on pipette. Twist cap to break seal, then remove cap from pipette. For dogs 10 kg body weight or less: For dogs of more than 10 kg body weight: With the dog standing still, part the coat between the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze firmly several times to empty the contents directly onto the skin. With the dog standing still, the entire contents of the Advantix pipette should be applied evenly to four spots on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the pipette on the skin and gently squeeze to expel a portion of the solution on the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog. Remove one pipette from the package. Hold applicator pipette in an upright position, twist and pull cap off. Turn the cap around and place the other end of cap back on pipette. Twist cap to break seal, then remove cap from pipette. Overdose (symptoms, emergency procedures, antidotes), if necessary No adverse clinical signs were noted in healthy puppies or adult dogs exposed to 5x overdosage or for puppies whose mothers were treated with 3x overdosage of the product. Withdrawal period(s) Not applicable.

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